Exams of retinal function [i

Exams of retinal function [i.e., electroretinograms (ERGs)], mutant rhodopsin localization, and ultrastructural features were not described. anti-rhodopsin antibodies. The outer segments, although shortened, contained well-packed discs. Proliferation of the endoplasmic reticulum as reported in expressing dominant rhodopsin mutations UPA was not observed. The accumulation of rhodopsin-laden vesicles likely represents aberrant transport of rhodopsin from the inner segments to the nascent disc membranes of the outer segments. It is possible that photoreceptor degeneration occurs because of a failure to renew outer segments at a normal rate, thereby leading to a progressive shortening of outer segments, or because of the loss of…
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