General Calcium Signaling Agents

Louis, MO, USA)

Louis, MO, USA). in China. EM possesses multiple pharmacological activities, including anticancer activity (Tabopda et al., 2008; Ooi et al., 2011, 2012), anti-protozoal activity (Gachet et al., 2010), melanogenesis inhibition activity (Hasegawa et al., 2010), bone regenerative activity (Ngueguim et al., 2012), and hepatoprotective activity (Lin et al., 1995). However, whether EM is an efficacious treatment option for human AML and CML remains unknown. In this study, we investigated the anti-leukemia properties and associated molecular mechanisms of EM23, a natural sesquiterpene lactone isolated from EM, in the K562 and HL-60 human CML and AML cell lines. Mechanistically, we demonstrated that…
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