Catechol methyltransferase

Unlike Z-FL-COCHO (potent CTSS inhibitor), BJ-2302 did not induce any cytotoxicity in MCF-10A normal breast epithelial cells

Unlike Z-FL-COCHO (potent CTSS inhibitor), BJ-2302 did not induce any cytotoxicity in MCF-10A normal breast epithelial cells. like a high-affinity target of BJ-2302 (IC90: 3.23?M) via a Src kinase assay and a drug affinity responsive target stability (DARTS) assay. BJ-2302 efficiently suppressed MDA-MB-231 cell invasion (Matrigel invasion assay) and metastasis (chorioallantoic membrane assay xenografted with MDA-MB-231-luc2-tdTomato malignancy cells). Unlike Z-FL-COCHO (potent CTSS inhibitor), BJ-2302 did not induce any cytotoxicity in MCF-10A normal breast epithelial cells. Additionally, BJ-2302 (1?mg/kg) strongly suppressed TNBC cell proliferation in vitro and tumor growth inside a xenograft mouse tumor model. The anti-metastatic and anti-tumor effects of…
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