06
Jan
Thus the epigenetic dysregulation arising from the loss of transcriptional corepressors may predispose malignancy cells to the cytotoxic effects of HDACis. Conclusion In the present evaluate, the mechanisms employed by ER corepressors to attenuate hormonal responses was analyzed to identify biological processes that may confer tamoxifen resistance in breast cancer and expose potentially effective therapeutic strategies to restore drug sensitivity. We spotlight a mechanism of gene repression common to corepressors previously shown to enhance the antitumorigenic effects of tamoxifen, which involves the recruitment of histone deacetylases (HDACs) to DNA. As an indication of epigenetic disequilibrium, the loss of ER corepressors…