21
Jan
Although in all groups of mice the IFN- content increased progressively after challenge, the levels attained by the immunized group were significantly higher than those of control groups in the whole observation period. The TNF- content was markedly lower in the lung and liver of immunized mice during the whole observation period. vaccinated mice. However, there is no difference between vaccinated and non-vaccinated mice in terms of PST-2744 (Istaroxime) the frequency of CD4+CD25+Foxp3+ T cells. Finally, we show that this vaccination confers a long-term protection against infection. Altogether, these data indicate that this oral vaccination of mice with Typhimurium expressing…