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Expression was confirmed using an anti-His tag antibody (red arrows in the second panel) and anti-CSP antibody (green arrow in the third panel). as phospholipid scramblase). Further, we show that HP1 interacts with a ~160?kDa hepatocyte membrane putative receptor (identified as carbamoyl-phosphate synthetase 1). Importantly, immunization of mice with the HP1 peptide partially protects them from infection by the rodent parasite infection of human hepatocytes in culture. The sporozoite ligand for hepatocyte invasion is a potential novel pre-erythrocytic vaccine candidate. Subject terms: Parasite biology, Pathogens After transmission of Plasmodium sporozoites from infected mosquitoes, parasites first infect hepatocytes. Here, Cha et…