Des Roches A, Nguyen M, Paradis L, et al

Des Roches A, Nguyen M, Paradis L, et al. ROC curve analysis for egg whiteCspecific IgE revealed an AUC of 0.63. There was no significant difference in age between patients who failed and those who exceeded (median = 8.8 years versus 7.0 years; p = 0.721). Based on our sample, SPT, egg whiteCspecific Roscovitine (Seliciclib) IgE and age are not good predictors of passing a baked egg challenge. However, there was a trend for more predictability with SPT wheal size. values were determined by using the Mann-Whitney test for comparison of independent samples. Roscovitine (Seliciclib) Receiver operating characteristic SPN (ROC) curve analysis was used to determine a threshold that would differentiate children who would react to baked egg from those who are tolerant. The relationship between sensitization status and outcome measure was analyzed using logistic regression. In addition, fitted predicted probability curves were created from the logistic regression models. RESULTS Fifty-two egg-allergic children (56% males) with a median age of 7.2 years (range, 2.2C18.0 years) underwent a baked egg challenge. Baseline characteristics of the subjects are shown in Table 1. At the time of OFC, most patients had other atopic conditions such as other food allergies, asthma, atopic dermatitis, and allergic rhinitis. Three subjects (6%) had a history of egg anaphylaxis. Before baked egg challenges, all subjects had at least one of the following assessments: (1) SPT to egg white or (2) blood test for egg whiteCspecific IgE. The majority (73% or 38 subjects) had both an SPT and an egg whiteCspecific IgE blood test performed before the OFC. The median egg SPT wheal size was 13 mm (range, 0C35 mm). The median egg whiteCspecific IgE was 1.99 kU/L (range, 0.35C13.00 kU/L). Four values were below the LLOD. Table 1 Baseline characteristics Open in a separate window SPT = skin-prick test. Forty-three subjects (83%) exceeded and nine subjects (17%) failed the OFC. The characteristics of the children who failed the challenge are presented in Table 2. None of the nine subjects with an egg SPT wheal size 10 mm Roscovitine (Seliciclib) failed the baked egg OFC. However, the likelihood of failing the challenge increased with increasing SPT wheal sizes as seen in Fig. 2. Among the subjects Roscovitine (Seliciclib) who failed the challenge, four subjects had a moderate reaction of a rash and/or itchy mouth, three subjects had a moderate reaction with emesis or abdominal pain, and two subjects had a severe reaction (anaphylaxis). One of the anaphylactic subjects was a 9-year-old boy with an egg whiteCspecific IgE of 1 1.52 kU/L. He did not have a previous SPT to egg. The other case of anaphylaxis was an 8-year-old lady with an egg whiteCspecific IgE of 6.10 kU/L and an egg white SPT wheal of 15 mm. An ovomucoid-specific IgE level was not performed in either subject. Neither of these subjects had a history of anaphylaxis. Both subjects improved after treatment with epinephrine but were hospitalized overnight for monitoring and discharged to home the next morning Roscovitine (Seliciclib) in good condition. Table 2 Characteristics of the children who failed the challenge to baked egg Open in a separate window One teaspoon of muffin or cake contained 10 mg of egg protein. One tablespoon of muffin or cake contained 40 mg.

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